氯胺-T 三水合物

Tosylchloramidesodiumtrihydrate(ChloramineTsodiumtrihydrate)是广泛厨房，实验室和医院的消毒剂。也用作空气清新剂和除臭剂中的杀生物剂。体外研究Gram-positivegrowthisreducedby95%to aftertosylchloramidetreatment,regardlessofdose,withorwithoutserum.Ecoli(gram-negative;with/withoutserum)isreduced94%to atantisepticconcentrationsof300and400ppm.At200ppm,Ecoligrowthisfullyinhibitedwithoutserumpresentandby50%withserum.At100and200ppm,cellviabilityremainsgreaterthan90%underallexperimentalconditions.A300-ppm,3-minuteexposuretotosylchloramideresultsincellviabilityofupto70%,withlongerexposuresproducinglowerviabilities.Serumdoesnotaffectcellviabilityinanycondition.体内研究Adose-dependentlChemicalbookysignificantDNAdamageintherattissuesandinflammationishistopathologicallynotedaroundtheterminalairwaysofthelunginbothmaleandfemalerats.The24-hexposureto50mg/Lofchloramine-Tistoxicforcrayfishandleadstosubstantiallossofenergythatbecameapparentduringsubsequentlyconductedphysicalstress.Tosylchloramidemaypotentiatethetoxicityofmanyxenobioticsviametabolicactivationand/oraccumulationofreactivemetabolites.TheactivitiesofCYP2E1,CYP1A1/2CYP2B1/2,CYP3A4andCYP4A1/2enzymessignificantlyincreaseaftertreatmentwith2.50,5and10mg/kgbw/daytosylchloramide,inadose-dependentmanner.Thiseffectisnotobservedaftertosylchloramidetreatmentatdoseof1.25mg/kgbw/day.